Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Several factors are expected to play a role in the in vivo fate of CNTs including the type of surface modification (physical coating versus chemical functionalization) and the degree of chemical functionalization. Since pharmacokinetic profiling of carbon-based nanomaterials is essential, both pharmacologically and toxicologically, this study attempts to determine the effect of the degree of MWNT chemical functionalization on their ensuing pharmacokinetic profile.